VueScan is compatible with the Epson Perfection 2450 on Windows x86, Windows x64, Windows RT, Windows 10 ARM, Mac OS X and Linux. If VueScan isn't working with the Firewire cable, try a USB cable, try a different Firewire port or a different Firewire cable. Epson driver for epson 2450 scanner free download - Epson TWAIN Scanner Driver, Epson Twain Scanner Driver, Epson TWAIN USB Scanner Driver, and many more programs. Downloads 18 Drivers and Manual for Epson Perfection 2450 PHOTO Scanner Scanners. Here's where you can download the newest software for your Perfection 2450 PHOTO Scanner. Download Epson Perfection 2450 Photo TWAIN Driver 5.71A for Vista/Windows 7 (Digital Camera / Webcam / Camcorder).